Mathematical Biology Seminar Daniel J. Cohen, Princeton University. Wednesday, January 13, 2021 3:05pm on Zoom Jousting, sheepdogs, and spies: paradigms to engineer and control collective cell behaviors. Abstract: The more we come to understand collective cell behaviors, the more we realize how central they are to multicellular life. This fundamental importance makes such behaviors as collective migration potent targets for strategies that would allow us to harness and direct collective cell behaviors for practical purposes. However, realizing such control requires approaching cellular collectives from an engineering and swarm theoretic perspective to first define relevant, fundamental rules governing a given collective process, and then build experimental tools to program these collective behaviors. Here, we will look at several case studies of this approach from my group: tissue tessellation based on multi-tissue interactions; bioelectric 'sheepdogs' to literally herd and program collective migration; and cell-mimetic materials to reprogram tissue dynamics from the inside-out.