Mathematical Biology seminar
  
              
              
              Jim Keener 
              University of Utah 
              "A  Model for Length Control of Flagellar Hooks  of
               Salmonella Typhimurium" 
              March 10, 2010 
              3:05pm in LCB 215
  
              
                    
              
               
              
              
              
              
              We present a mathematical model for the growth and
              length regulation of the hook component of the flagellar
              motor of Salmonella Typhimurium.  Under the
              assumption that the molecular constituents are
              translocated into the nascent filament by an ATP-ase and
              then move by molecular diffusion to the growing end,
              where they polymerize into the growing tube, we find
              that there is a detectable transition from secretion
              limited growth to diffusion limited growth.  We propose
              that this transition can be detected by the secretant
              FliK, allowing FliK to interact with FlhB thereby
              changing the secretion target of the type III secretion
              machinery and terminating the growth of the hook.
              
 
  
              
 
  
              
 
  
          
           
        
        
         
        
 
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