Mathematical Biology Seminar Cecilia Diniz Behn, University of Utah, Wednesday, October 29, 2025 12:30 pm in LCB 222 Mathematical modeling of noradrenaline dynamics across behavioral states Abstract: Wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep are characterized by differential release of neuromodulators such as noradrenaline (NE). The noradrenergic locus coeruleus (LC) promotes wakefulness and exhibits state-dependent changes in neuronal activity and NE release. In previous work, we developed a firing rate model formalism that describes both firing rate and associated neurotransmitter release to explore the differential effects of neurotransmitter agonists and antagonists acting on LC. More recently, experimental advances have described the LC-NE system with higher temporal resolution and revealed infraslow extracellular oscillations in NE during NREM sleep and asymmetry in the dynamics of NE rise and fall during REM sleep. In current work, we refine our modeling formalism to account for the fine details of LC-NE dynamics and explore the implications of this refinement in the context of sleep-wake network models.